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Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 171-176 doi: 10.1007/s11684-009-0027-4

Abstract: Recombinant human growth hormone (rhGH) has been widely used in the clinical treatment of growth hormoneof the current study was to evaluate the efficacy and safety of rhGH injection for the treatment of growthhormone deficiency (GHD) in children in China.insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), and boneWe conclude that rhGH injection is a safe and effective drug for treatment of growth hormone deficiency

Keywords： recombinant human growth hormone     injection     growth hormone deficiency    

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Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children duringtherapy with recombinant human growth hormone

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 580-585 doi: 10.1007/s11684-017-0585-9

Abstract:

This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of childrenwith idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growthhormone therapy.In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be consideredwhen FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.

Keywords： therapeutic     idiopathic short-stature children     free T4     the first year     recombinant human growth hormone    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: However, a number of studies have shown that multiple types of pituitary hormone receptors are widelyEach pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in thesehormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin when they act on non-classicalorgans were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissueThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophichormone     prolactin    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: system, we further demonstrated that transient expression of and can significantly inhibit chicken growthhormone (GH)- or prolactin (PRL)-induced luciferase activities of Hep G2 cells expressing cGH receptortogether, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators of cytokine/hormone

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Strategic Study of CAE 2015, Volume 17, Issue 1,   Pages 67-73

Abstract:

The mature peptide domain of insulin-like growth factor-I from Platichthys stellatus were amplifiedThe present results would be helpful for better understanding the roles of IGF-I in growth regulationand development of high effective additive for growth promotion of Platichthys stellatus.

Keywords： Platichthys stellatus； insulin-like growth factor-I； prokaryotic expression； bioactivity    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, although

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 16-20

Abstract: of estrogen and progestin, secondarily leading to suppression of endogenous gonadotropin and gonadal hormoneDuring the hormone-free interval (HFI), COCs users experience activation of their pituitary–ovarian

Keywords： COCs     HFI     hormone     follicle    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.

 

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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Economic Growth Model Based on Six Basic Factors of Production—Xu Growth Rate Equation

Shou-bo Xu,Zong-yuan Huang

Frontiers of Engineering Management 2014, Volume 1, Issue 2,   Pages 160-175 doi: 10.15302/J-FEM-2014024

Abstract: This paper proposes an economic growth model based on the Six Basic Factors of Production and Xu GrowthRate Equation for the first time, which fills-in the deficits of the New Classical Economic Growth Modeldecades, the consumption of six basic factors of production had complicated relations with economic growthrate of the basic factors of production was meager, but the economy witnessed relatively rocketing growthrate; in some years, the factors of production consumption rate was very high, but the economy growth

Keywords： six basic factors of production     economic growth model     Xu Growth Rate Equation    

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The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 86-92

Abstract: >- estradiol (E2) were found to increase during the peak phase of vitellogenic growth

Keywords： Alosa sapidissima     ovary development     oogenesis     histology     morphology     steroid hormone    

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Copper fractal growth during recycling from waste printed circuit boards by slurry electrolysis

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1405-7

Abstract:

• Copper fractal growth was observed during WPCBs recycling by slurry

Keywords： Dendritic copper     Fractal growth     WPCBs     Slurry electrolysis    

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Growth and abscisic acid responses of

Yue LI, Liqiang WAN, Yufei WANG, Xianglin LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 1,   Pages 80-86 doi: 10.15302/J-FASE-2017199

Abstract: The response of alfalfa to water stress at different growth stages was generally similar, but varied

Keywords： abscisic acid     alfalfa     drought response     growth stage     water deficit    

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Availability growth models and verification of power equipment

Jinyuan SHI, Jiamin XU

Frontiers in Energy 2021, Volume 15, Issue 2,   Pages 529-538 doi: 10.1007/s11708-019-0624-0

Abstract: The general availability growth models for large scale complicated repairable system such as electriccalculation formulas for the maintenance coefficient, mathematical expressions for general availability growthAvailability growth models for electric generating units, power station auxiliaries, and transmissionand distribution installations are given together with verification examples for availability growthmodels conform to rules of availability growth tendency of power equipment.

Keywords： station auxiliary     transmission and distribution installation     reliability     availability     availability growth    

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Title Author Date Type Operation

Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Journal Article

Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children duringtherapy with recombinant human growth hormone

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

Economic Growth Model Based on Six Basic Factors of Production—Xu Growth Rate Equation

Shou-bo Xu,Zong-yuan Huang

Journal Article

The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Journal Article

Copper fractal growth during recycling from waste printed circuit boards by slurry electrolysis

Journal Article

Growth and abscisic acid responses of

Yue LI, Liqiang WAN, Yufei WANG, Xianglin LI

Journal Article

Availability growth models and verification of power equipment

Jinyuan SHI, Jiamin XU

Journal Article